Research achievements on anticancer effects and the reduction of side-effects related to anticancer drugs
Research achievements on prevention of lifestyle-related diseases and reduction of disease risks
Research achievements to live a comfortable life
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Extraction of high molecule was impossible with traditional technology
Marine Products Kimuraya started extracting fucoidan from mozuku when it was testing fucoidan’s antibacterial activities against E. coli O-157.
During this search for the active compound for E. coli O-157, we fractionated the molecular weight of hydrothermally extracted substances from mozuku, and eventually we were able to identify fucoidan.
To refine fucoidan, we tried to use traditional refining methods using electro-dialysis and a quaternary ammonium salt, but this was difficult to scale up and some of the chemicals were not suitable for food use.
We also conducted research using microorganisms and collected microorganisms from various locations. We undertook research aiming to refine fucoidan by utilizing the ability of microorganisms to decompose various materials. However we were not able to find microorganisms suited for food use.
After trial and error at the laboratory, we scaled up the process, and experimented with extracting and refining technology on pilot plant scale.
The more we tried to reach our target of high-polymer fucoidan in a state similar to its nature state, the more viscous the solution became, and the more time-consuming the production process became.
Conversely, extracting in a lowered viscosity reduced the molecular weight or detached the sulfate group. It was difficult to extract high-polymer fucoidan.Finally we were able to control the extraction conditions and standardized the production procedures and quality control, to further developed our technology, "Ultra filtration F technology", and solved all of our problems.
Thus, we succeeded in producing a consistent and specific quality of high-polymer fucoidan.
